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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well end in an increase in methadone plasma concentrations, which could trigger most likely fatal respiratory depression. Also, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also bring about a rise in